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KMID : 1225720210130060939
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Allergy, Asthma & Immunology Research : AAIR
2021 Volume.13 No. 6 p.939 ~ p.944
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Predicting Factors of Severe COVID-19 in Patients With Asthma: A Korean National Cohort Study
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Lee Hyun
Choi Ha-Young
Lee Sun-Kyung
Park Tai-Sun
Park Dong-Won
Moon Ji-Yong
Kim Tae-Hyung
Sohn Jang-Won
Yoon Ho-Joo
Kim Sang-Heon
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Abstract
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As there are limited data on the disease course of and factors predicting severe coronavirus disease 19 (COVID-19) in patients with asthma, this study aims to perform a detailed analysis of the clinical course of asthmatic patients with COVID-19 and evaluate factors related to severe infection. Of the 5,628 patients confirmed with COVID-19, 128 (2.3%) had asthma. Among the 128 asthmatic patients, 32 (25%) had severe COVID-19 and 96 (75%) had non-severe COVID-19. Among asthmatic patients, those with severe COVID-19 were significantly older and had more dyspnea and fever, more comorbidities, and lower lymphocyte and platelet counts than those with non-severe COVID-19. In multivariable logistic regression analysis, chronic obstructive pulmonary disease (adjusted odds ratio [aOR], 6.49; 95% confidence interval [CI], 1.18?41.81), low lymphocyte proportion (aOR, 0.91; 95% CI, 0.86?0.97), and low platelet count (aOR, 0.99; 95% CI, 0.98?0.99) were independently associated with severe COVID-19.
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KEYWORD
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Asthma, COVID-19, chronic obstructive pulmonary disease
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